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Proteomics: From biological discovery
to candidate biomarker
Connie Jimenez
Head of OncoProteomics Laboratory,
VU Medical
Center / Cancer Center Amsterdam
The research field that deals with the large-scale
comprehensive analysis of proteins (expression,
modifications, interactions) is called proteomics.
Recent developments in proteomic technology, most
notably mass spectrometry, offer great potential to
yield insight into biological and disease mechanisms as
well as novel biomarkers that are translatable to
routine clinical use. In particular, quantitative
proteomics based on protein separation by
liquid-chromatography (LC) coupled to mass spectrometry
(MS) has emerged as a powerful approach for identifying
and quantifying hundreds to thousands of proteins in
complex proteomes.
This masterclass will focus on the question whether
proteomics has delivered its promises. Are we there yet?
Are we on schedule? What progress has been made in the
field of basic biology and biomedical/clinical
applications?
A panel of experts will reflect on the above questions
from different angles (technology, basic science,
biomedical applications).
Confirmed scientists on the
panel include:
Sander Piersma (Oncoproteomics Laboratory, VUmc)
Paul Hensbergen (Biomolecular Mass Spectrometry
Unit, LUMC)
Ka Wan Li (Molecular and Cellular Neurobiology,
VU)
Madalina Oppermann (Applied Biosystems)
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