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Toxicogenomics &
Bioinformatics: a pathway perspective
Rob Stierum
Head Toxicogenomics,
TNO Quality of Life, Zeist
Perry Moerland
Assistant Professor
Bioinformatics, Bioinformatics Laboratory, Academic
Medical Center, Amsterdam
Purpose of this masterclass is to briefly outline and
discuss with participants the basic principles of
toxicology. The new discipline of toxicogenomics,
involving the implementation of genomics technologies in
toxicology to predict and unravel mechanism of toxicity
will be outlined. The implications of toxicogenomics in
the developments of alternatives to animal testing will
be highlighted. Further, bioinformatics approaches
specifically usefull for toxicogenomics will be
illustrated with emphasis on pathway and network
analysis. Together, the masterclass will provide an
overview and promote discussion on how this new
promising technology is revolutionizing toxicology as an
applied science.
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